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Using a concordance plot to examine the degree of correlation between the MLPA and PRT systems, we demonstrated an R value of 0.91.
However, by combining the two techniques using a concordance plot we were able to unambiguously assign copy number to these samples.
The high degree of clustering exhibited by the histogram plots of raw unrounded copy number and the high degree of correlation and clustering shown in the concordance plot leaves little doubt as to the assignment of integer copy number.
Interestingly, when we performed the concordance plot between the two assays, the R between the two assays was higher than expected (R 0.87), yet the overall cluster quality was quite poor, suggesting that real-time QPCR has a reasonable level of accuracy but exhibits poor precision.
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Population PK model was evaluated using diagnostic plots such as concordance plots, weighted residual error plots, weighted residual error distribution plots and random effects distribution plots, and simulation-based diagnostics such as posterior predictive check.
The paper is made much harder to comprehend due to the many cross-comparisons, in the form of Bland and Altman and four-quadrant concordance plots, which show agreement between the three pulse contour methods.
Under perfect concordance this plot will behave like y = x and under random sampling it will behave like y= x 2. The acceptance region at a given level of significance for the hypothesis of random sampling can be constructed by the hypergeometric distribution [ 12].
Averaged relative genotype concordance is plotted in Figure 4. CCN analysis was performed using the CNAT4.1 (Affymetrix).
Therefore, SVV correlated with its arterial pressure surrogates (Pearson's product moment r > 0.7) and showed a high concordance rate (quadrant plot analysis) and acceptable mean angular bias and radial limits of agreement (polar plot), except with SPV.
In neurosurgical patients requiring extensive vasoactive support, CO values obtained by calibrated PCCO showed clinically and statistically acceptable agreement with TPCO-measurements, but the results from concordance and polar plot analysis indicate an unreliable trending ability.
Trending analysis was conducted by four-quadrant plot concordance assessment using an optimised exclusion zone of <5% ΔCI on changes at timepoints M2 to M4 relative to baseline (M1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com