Concordance of the methylation pattern found in tissue and serum specimens indicates the potential utility of blood-based detection of breast cancer.
A striking concordance in the pattern of gene regulation across the entire screen was observed when the VHL-responsive genes were compared to the hypoxia-responsive genes in 786-0/VHL 786-0/VHL
However, the use of multiple criteria and strict cut-offs to refine the set of candidate genes, the agreement with existing literature regarding the immune related functions of many candidate genes and the concordance of the expression patterns of top candidate genes reported here with the corresponding expression patterns from an independent dataset, all lend further support to our predictions.
However, the low rate of LOH recorded in blood, the lack of concordance of the LOH patterns in the different tissues, and the small and coincidentally created set of microsatellite markers indicate that the method needs to be further improved.
The tallest x and o characters represent areas of absolute concordance between the patterns chosen for analysis.
Overall, these correlations, which were largely unchanged when controlling for sequence length (supplementary table S6, Supplementary Material online), suggest remarkable concordance between the patterning of DNA methylation, when present, and histone modifications across evolutionary time (Nanty et al. 2011).
Time-course analysis showed that this fragment was detectable 4 hours after MG132 treatment in Cas-FL MEFs, markedly increased thereafter, and reached maximal levels at 16 hours post-treatment, in concordance with the patterns of PARP cleavage and cell apoptosis.
Although we had observed concordance of the focal staining pattern in superficial tumours, the total level of VEGF mRNA as assessed by RNAse protection did not correlate statistically with the CA IX score in these cases.
Overall, we found a good concordance of the two evolutionary patterns in terms of changes in point mutations, CNAs and rearrangements, suggesting that the mutational processes acting at these three levels were broadly in concert over time and across subclones during evolution.
To assess the concordance of expression pattern by RNA-Seq and microarrays, all genes expressed by RNA-Seq were evaluated as to whether they were identified as expressed in all microarrays, a subset of microarrays or not represented on the microarray.
By considering different assumptions about spatial bias, we can assess the concordance of spatial patterns between AOD and PM2.5 and investigate the assumption that the spatial pattern in AOD represents signal that is informative about PM2.5.
