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There is an increased risk of gastrointestinal toxicity when NSAIDs and selective serotonin reuptake inhibitors are taken concomitantly compared with taking either agent alone, and this is greater than the additive risk [ 50].
Concomitantly, compared with their expression in embryos injected with the p53 mRNA alone, the expression of all p53 target genes, including Δ113p53, mdm2, p21 and bax, was downregulated by the injection of def mRNA in the co-injected embryos at 6 hpi.
From 8 h after PDT, the level of active caspase-9 decreased concomitantly compared with a constant high presence of active caspase-3 during the recovery time, which remained up to 72 h post PDT, suggesting activation of other apoptotic pathways.
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An additive effect on levels of intact GLP-1 has also been reported in patients with T2DM receiving metformin and vildagliptin concomitantly as compared with drug-naïve patients receiving only vildagliptin [ 13], which further supports the use of this combination of drugs [ 41, 42].
The radiopotentiating effect of BMS-690514 was reduced when BMS-690514 was administered concomitantly with radiation as compared with a sequential schedule.
It was observed that Zr can also concomitantly improve strength and ductility compared with the alloy modified by Sc only.
Compared with mice concomitantly exposed to filtered air, the CAPs exposed mice had a significant increase in white adipose tissue PAI-1 mRNA (Figure 1D).
Giving sorafenib and CDDP concomitantly, ERK1/2 phosphorylation was lower compared with control, however, did not reach the effect of sorafenib alone.
In addition, to determine the muscle toxicity risk associated with drug drug interactions, the incidence of muscle toxicity among patients who had concomitantly used interacting drugs was compared with that in patients who did not.
The microstructure study revealed that the muscle fibers of pre-cooked shrimps were less attached with concomitantly higher shrinkage of the sarcomere, compared with those of the raw counterpart.
Mice systemically treated with intravenous rAAV2- IL27 injections at either 6 or 14 weeks of age exhibited long-term elevated levels of serum IL-27 with concomitantly reduced levels of IL-17 compared with sera from mice injected with rAAV2- LacZ or saline out to 20 weeks post-inoculation.
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