Patients were included if, during EGDT, they concomitantly achieved a central venous pressure (CVP) of ≥8 mm Hg and a mean arterial pressure (MAP) of ≥65 mm Hg while registering a ScvO2 < 70%.
This observation suggests that multiple pathways need to be activated concomitantly to achieve optimal effects on lifespan and healthspan through chemical treatments.
While these objectives are interrelated and opportunities often exist to achieve them concomitantly in the same exercise, it is critical to define the priority objective for the exercise because different objectives have different implications for exercise design.
In the case of arsenic mitigation, this means ensuring that interventions are targeted to those areas where exposure has been confirmed, and that those interventions provided achieve significant reductions in arsenic exposure without concomitantly causing substantial increases in other risks such as water-related infectious disease.
Hb-based blood substitutes (HBBS) have theoretical advantages over other fluids in the resuscitation of neurocritical care patients, because they have the potential to achieve the CBF-enhancing effects of hemodilution, while concomitantly maintaining, or even raising, CaO2.
In organisms that metabolize starch or glycogen, the degradative and phosphorylating steps are achieved either concomitantly by an ATP-independent pathway or separately by an ATP-dependent pathway in which phosphorylation is catalyzed by hexokinase (for reviews, see [108], [109].
Teramoto et al (1995) examined whether E1-, E3-deleted adenovectorsectors affect the cell viability of human airway cells in primary culture, using trypan blue exclusion, and demonstrated that, as the MOI of adenovirus vectors is increased (to achieve effective gene transfer), the viability of infected cells is reduced concomitantly via apoptotic change.
We concomitantly used a novel method, "holding the cervix", with the Balloon to prevent Balloon prolapse and achieve hemostasis.
Indeed, because selective modulation of P-gp in cancer cells (and not at physiologic sites) will be difficult to achieve, attempts to circumvent MDR will need to consider the profound effects on the pharmacokinetics and distribution of concomitantly administered drugs.
In order to achieve a broader, more even X-ray field and eliminate speckle, a spinning piece of paper may be used as a rotating random-phase screen to diffuse the hard X-ray beam, but this will concomitantly decrease the magnitude of the complex degree of second-order coherence.
