Higher expression of Hb Q-Iran with lower levels of MCV in carriers of this hemoglobin was observed with concomitant presence of this variant with − α3.7 kb mutation [ 21].
In total, 28.6% of the study population was predicted to have reduced activity of the CYP2D6 or CYP3A4/5 enzymes due to either genetic variants or concomitant medications.
Our results indicate that both pharmacogenomic variants and concomitant medications may affect the pharmacokinetics and ultimately the efficacy and tolerability of AD medications.
Our results indicate that approximately 29% of our study population would have reduced activity of either CYP2D6 or CYP3A4/5 activity due to either pharmacogenomic variants or concomitant medications (Table 2).
Taken together, these results suggest that concomitant inheritance of rare variants in FANCA, FANCP/SLX4 and GEN1 on the specific genetic background of this familial case, could lead to increased genomic instability, hematopoietic dysfunction, and higher risk of childhood leukemia.
From a genetic perspective, the MET Δ7 – 8 mutant resembles the auto-active EGFRvIII variant which occurs concomitant with EGFR amplification in 25 64 % of all GBMs [ 51, 59].
Benign feature of Hb D-Punjab was confirmed by two separate reports of concomitant presence of this structural variant with β-thalassemia mutation of IVSII-1 G A that produced a minor β-thalassemia picture [ 25, 26].
By enabling concomitant analysis of host genomic variants with their respective microbiome community profiles, we can begin to address a number of crucial gaps in our understanding.
Others argue that, in "real life," opposing to the clinical trial setting, there are abundant factors, such as body weight, age, renal and liver function, concomitant interacting drug and genetic variants, and probably many other unknown causes that influence the plasma levels and the anticoagulant effect of all of these agents.
He remained stable for the next 7 years, but then he began to manifest rapid clinical progression, which raised the possibility of an unusual variant of asbestosis, a concomitant interstitial process, or an unrelated disease.
