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Patients were considered concomitant users of LABA and ICS upon initiation of a combination LABA/ICS product or if they initiated a LABA and received a dispensing of an ICS on the same day.
It must be noted that the analysis examining the risk of zoster among concomitant users of inhaled corticosteroids and inhibitors of pertinent cytochrome oxidase enzymes had limited power since matched controls could only be identified for 475 cases of zoster.
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However, although there is a corresponding kernel-level processing activity, no concomitant user-level processing was observed in this experiment to justify a real performance gain for user processes.
Incidence of hypoglycaemia events were compared between concomitant SU users and non-SU users using Fisher's exact test.
Among the concomitant MTX users this was only 6%, while it was 26% in patients not receiving MTX [ 28].
Hence, the proportion of concomitant LABA/ICS users is likely to be overestimated in our study.
In our study, the proportion of concomitant LABA/ICS users increased from 52.0%too 57.6% between 2004 and 2008.
According to urine analysis at the day of assessment, nine of these concomitant drug users had consumed benzodiazepines or benzodiazepines and cannabis combined, 13 patients had used cannabis only, 8 patients had used cocaine with or without additional cannabis or benzodiazepines.
According to the pattern of LABA and ICS prescriptions, patients were assigned to the following five mutually exclusive categories: "concomitant LABA and ICS users", "switchers", "non-concomitant LABA and ICS users", "LABA users without ICS", and "ICS users without LABA" (Table 1).
For the five patient categories ("concomitant LABA and ICS users", "switchers", "non-concomitant LABA and ICS users", "LABA users without ICS", and "ICS users without LABA") and the subgroup categories "combined inhalers", "separate inhalers", and "combinations" the number of patients and proportions were calculated and stratifications by age, sex, and calendar year were performed.
The proportion of "concomitant LABA and ICS users" increased from 52.0 to 57.6% within the study period, whereas for "LABA users without ICS" a slight decrease from 6.5 to 5.4% was found.
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CEO of Professional Science Editing for Scientists @ prosciediting.com