Discontinuing shRNA expression by doxycycline administration to mice with established liver tumors caused P53 reactivation and concomitant tumor regression.
Results of recent clinical trials using NY-ESO-1 [ 9] and MAGE-3 [ 10] as target antigens have been promising in terms of inducing antigen-specific T cells in vivo and, in some cases, concomitant disease regressions.
Complete sustained regression, concomitant with massive differentiation and/or apoptosis, and partial regression are both observed.
It is generally accepted that transgression and regression concomitant with global warming and cooling lead to worldwide dispersal and diversification of sea animals.
The placebo response has been well described in asthma studies and various explanations have been proposed, including suggestibility, natural disease variability, improved compliance with concomitant treatment and regression to the mean [ 15, 16].
After controlling for socioeconomic and demographic factors, site, treatment duration, adherence and concomitant TB treatment, the regression analyses showed that the employed were significantly less likely to receive the DG than the unemployed (p < 0.001).
These patients had significant developmental impairment as early as the first few months of life, along with evidence of clinical regression and concomitant brain volume loss as observed from sequential MRI scans.
Subsequently, experiments in a rat glioma model suggested that even angiogenic tumours initially co-opt normal blood vessels after which a host defence response, governed by angiopoietin-2 expression on the co-opted endothelial cells, causes blood vessel regression with concomitant hypoxia and vascular endothelial growth factor (VEGF -mediated angiogenesis (Holash et al, 1999).
Future work include MCMC methods with censored data and regression problems with concomitant information.
