This is evident in our modeling perspective, as possibly energy-related changes in lactate fluxes are independent of concomitant function-related variations in glutamate-glutamine cycle (see Figure 7, that essentially shows a lack of correlation between lactate shuttling and transmitter cycling).
Recognising this issue, some clinical trial protocols will document lists of medications that in their context are considered to carry these risks, for example, "any concomitant medications that may cause QTc prolongation or induce Torsades de Pointes (see the Appendix for the list of medications in Tables 1 and 2) or induce CYP3A4 function" and "concomitant use of CYP3A4 inhiibitors or inducers.
Concomitant liver function, liver disease, and the local liver environment have a huge impact on treatment outcomes.
Multiple studies since then have shown an adverse effect of baseline diabetes status on concomitant cognitive function and cognitive decline on follow-up.
Initially, bilirubin and other concomitant liver function tests were assessed as categorical variables in quartiles (Models 1 5) adjusted for each other and the above described covariates.
Generally, the UC PL arises from the 4f 4f orbital electronic transitions with concomitant wave functions localized within a single lanthanide ion.
Based on these distinctive cytokine secretion patterns and concomitant effector functions, CD4+ T cells can be divided into at least two major subsets (Fig. 2).
In situ hybridization detecting the mature miRNA demonstrates that the mutation does not affect processing, suggesting that mutant miR-96 might cause hearing loss through a concomitant loss of function and gain of function.
Age, disease, comorbidities, concomitant medication, organ function and patients' compliance may partly explain the differences.
Given the results of combined ACL and ALL reconstruction compared to traditional ACL reconstruction in regards to re-rupture rate, return to play and rotational stability, it was concluded that the ALL has an important function concomitant to the ACL.
