Sentence examples similar to concomitant driver from inspiring English sources

Because the MET signaling pathway could crosstalk with other signaling receptors and MET amplification could be concomitant with other oncogenic drivers, the role of de novo MET amplification as primary oncogenic driver remains controversial in NSCLC.

Furthermore, the concomitant loss of the OK371- Gal4 driver (a putative glutamatergic label) and ectopic activation of the Cha7.4-Gal4 driver (a putative cholinergic label) suggest that there might be a change in neurotransmitter identity of the LALv1 lineage from wild-type glutamatergic to transformed cholinergic identities, similar to the cholinergic identity of wild-type antennal lobe neurons.

Recent research has focused on dual blockade of HER2 (trastuzumab-lapatinib; trastuzumab-pertuzumab) and concomitant blockade of the endocrine driver and other pathways such as the PI3K/AKT/mTOR pathway (everolimus-exemestane), HER2 (trastuzumab/lapatinib-endocrine therapy) and the cell cycle through cyclin-dependent kinase inhibition (letrozole-palbociclib).

The Abu Dhabi policy agenda 2030 stresses that STEM should be the primary driver of the future economy and concomitant creation of jobs that is based on innovation, largely derived from advances in science and engineering.

Unfortunately, it was not possible to detect concomitant molecular alterations in the present case, but oncogenic drivers out of EGFR may explain the resistance to EGFR-TKI in EGFR-mutated SCLC.

Mathematical modeling approaches suggest that invasion efficiency can be a significant driver of peak parasite density during an infection and concomitant pathogenesis.

Similarly, PIP and DIP joints may be inflamed either due to PsA or (secondary or concomitant) symptomatic osteoarthritis, and it is currently impossible to reliably identify the true driver of inflammation by means of imaging methods alone [ 36, 37].

Consequently, the expression of Gal4-VP16 from the driver construct transactivates the UAS of the responder construct, leading to the concomitant transcription of DsRed and parkin.

We also found concomitant BMAL1 and TYMS overexpression indicating that this clock gene may also be an important driver of mesothelioma progression.

Although studies suggest that ligand-independent HER2 HER3 heterodimers represent a trastuzumab-sensitive oncogenic driver in HER2-positive breast cancer [ 14, 15], one can hypothesize that the concomitant high expression of HER3 or its ligands in HER2-positive tumors may confer escape from trastuzumab inhibition.

The main cost drivers were costs associated with contact with health care professionals and use of concomitant medications, when comparing BoNT-A treatment with best supportive care.