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Concomitant dosing of antiXa (laboratory) and ACT (Hemocron®) was conducted two times a day on the same sample throughout the ECMO period.
We conclude that concomitant dosing with a cardiac stimulant and endothelin antagonist can partially reverse loss of physical performance capacity under hypobaric hypoxia, independent from improving blood oxygen saturation.
Mean systolic and diastolic BPs were similar after concomitant dosing of sildenafil 100 mg with either sitaxentan 100 mg or placebo.
Such a situation was described for droperidol and ondansetron where, despite of lack of exposure modification after concomitant dosing, the QT interval was prolonged, but the observed prolongation was not proportional to the QT prolongation observed for two drugs given separately (69).
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The ability of fibrin-bound ephrin-B2 to act as ligand for endothelial cells was preserved, as demonstrated by a concomitant, dose-dependent increase of endothelial cell binding to engineered ephrin-B2 fibrin ephrin-B2 fibrintro.
The α-helical content gradually increases upon increasing the TFE concentration from 0 to 25% and then reaches a plateau, while no concomitant dose-dependent increase in the content of β structure is detected (data not shown).
αSMA expression occurred in the treated cells with a concomitant dose-dependent production of TGF-β [ 36].
In the first step of the study, a concomitant dose-finding was conducted in order to assess the recommended OHP dose.
These changes displayed a close correlation with a concomitant dose-dependent enhanced density of mast cells and staining for hyaluronic acid.
ICI but not TAM inhibited ER-mediated gene transcription and resulted in a concomitant dose-dependent reduction in ERα levels, while having no effect on ERβ.
With the second and third occurrences of grade 3 skin toxicity, cetuximab therapy may again be deferred for up to two consecutive weeks with concomitant dose reductions to 200 and 150 mg m−2, respectively.
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