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Finally, we address the attractive concept of concomitant delivery of antigens and immunopotentiators.
Overall, the concomitant delivery PTX and NuBCP-9 loaded NPs showed superior activity than that of PTX and NuBCP-9 alone treated mice.
For example, side effects might be decreased upon encapsulation of the adjuvant and the concomitant delivery of antigen and adjuvant is a very promising tool for increasing efficacy.
The concomitant delivery of two agents that act synergistically allow the administration of lower concentrations of each drug increasing their combined antitumor efficacy and decreasing their toxicity.
Concomitant delivery of recombinant NEP would neutralise the effects of bradykinin and other peptides and might result in significant tumour regression.
These studies found that it is theoretically possible to achieve tumour dose escalation in MRS-identified intraprostatic tumour deposits without concomitant delivery of escalated doses to the urethra.
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These polymer-based systems can serve not only a biomaterials-based function, such as the separation or bulking of tissue, but also as concomitant drug delivery systems for the local delivery of therapeutics.
In the mouse embryo, where sFRP-3 affects axis elongation similarly to its effect in Xenopus [20], the concomitant transplacental delivery of both sFRP-3 and EGF (but not of FGF8) restored a normal embryo morphology in the majority of the embryos and also restored sFRP-3-dependent inhibition of myogenesis as it does in vitro.
An increased angiogenic ratio was associated with an increased risk of a severe hypertensive disorder and concomitant preterm delivery.
In confirmation of this concept, it was recently reported that anti-VEGF treatment of subcutaneous melanoma grafts results in vessel normalisation and concomitant better delivery of MRI contrast agents and oxygen to the tumour [ 58].
To perform kilovoltage (kV) cone beam computed tomography (CBCT) imaging concomitant with the delivery of megavoltage (MV) RapidArc treatment, and demonstrate the feasibility of obtaining MV-scatter-free kV CBCT images.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com