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Several studies have shown that the association between inflammatory markers and the severity of CAD are weak and are mostly explained by concomitant burden of cardiovascular risk factors.
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Age, gender, education, marital status and concomitant drug burden were obtained through self-reports.
Univariate analysis showed that concomitant drug burden predicted a greater adherence to therapy (P=0.018).
Concomitant drug burden was defined as the assumption of additional drugs related to diseases other than CML (yes vs no).
Cancer is a major cause of illness and death in Western society and is associated with a heavy concomitant economic burden.
Factors predicting adherence to imatinib therapy are group assistance, being informed, concomitant drug burden, managing side effects, and reminders to take the medicine [ 34- 36].
The final multivariate model identified concomitant drug burden, greater level of social support and satisfaction with information received (on the impact of therapy on one's QoL) as independent factors associated with optimal adherence (Table 4).
This study suggests that a higher level of social support, satisfaction with information received and concomitant drug burden are the main factors associated with an optimal adherence to long-term imatinib therapy in CML patients.
This study suggests that a higher level of social support, satisfaction with information received and concomitant drug burden are the main factors associated with greater adherence to long-term imatinib therapy.
The best multivariate model identified the two following factors: concomitant drug burden (odds ratio (OR)=1.653, 95% confidence interval (CI), 1.105 2.472) and time between CCyR and adherence evaluation (OR=0.857, 95% CI, 0.748 0.983).
Our results that a concomitant drug burden was associated with an optimal adherence to therapy lend support to previous data by Noens et al (2009) who showed an association between more medication to be taken daily and better adherence in CML patients undergoing imatinib therapy.
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