Sentence examples for concomitant attenuation of from inspiring English sources

We hypothesized that CYP2E1-mediated oxidative stress causes M1 polarization in experimental NASH, and that nitric oxide (NO) donor administration inhibits CYP2E1-mediated inflammation with concomitant attenuation of M1 polarization.

This was accompanied by increased apoptosis and concomitant attenuation of Notch-1 and NF-kappaB and down-regulation of NF-kappaB downstream genes, such as matrix metalloproteinase-9 and vascular endothelial growth factor, resulting in the inhibition of pancreatic cancer cell invasion through the Matrigel.

However, with increasing evolutionary age, we observed a significant increase in the frequency of both partial and chimeric duplicates as well as a concomitant attenuation of duplication spans.

AGE restriction normalized AGER1, SIRT1, and SIRT1-dependent NF-κB p65 deacetylation levels, and there was a concomitant attenuation of proinflammatory mediators (i.e., RAGE and TNF-α) (9).

Proliferative index Ki67 was reduced in metastatic deposits of 2H6-treated mice only (Fig.  4f), and we noted concomitant attenuation of Notch target genes (Hes1, Hey1, Hey2, HeyL), as well as key mediators of metastasis, such as periostin, MMP7, MMP9 [ 14, 15] (Fig.  4g, h).

As a consequence of this process the virus becomes more adapted for the embryo, reflected by more efficient replication and higher pathogenicity for the embryo, with concomitant attenuation for chickens and in some cases loss of immunogenicity.

In addition, a decrease in TGM-2 activity has been reported to result in concomitant attenuation in cell adhesion [37], which may for example, facilitate migration of abnormal pterygium tissue towards the central cornea.

After application of APAP, mice lacking TNF-α receptor as well as mice treated with anti-TNF-α antibodies showed a reduction in the neutrophil response and a concomitant significant attenuation of liver damage [ 38, 39].

Taken together, we have demonstrated that, in GLO1 Tg rats, age-related acceleration in glycative and oxidative stress was mitigated and age-related endothelial dysfunction was ameliorated, concomitant with attenuation of age-related eNOS (Thr495) phosphorylation and eNOS (Ser1177) dephosphorylation, resulting in increased NO bioavailability and amelioration of endothelial dysfunction.

To evaluate the ability of two novel coiled test stimulation lead designs to reduce or eliminate undesired migration and concomitant loss or attenuation of responsiveness to sacral nerve stimulation (SNS) associated with standard percutaneous nerve evaluation (PNE) leads.

Treatment of animals bearing the clone 20 variant with 5′-dF Urd led to the disappearance of PIF from the tumour, serum and urine concomitant with the attenuation of the development of cachexia.