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Thus, we antagonized N-methyl-D-aspartate (NMDA) receptors with 2-amino-5-phosphonovaleric acid (AP5) in the pigeon nidopallium caudolaterale, the functional analogue of mammalian prefrontal cortex, during the concomitant acquisition and extinction of conditioned responding to two different stimuli.
The appearance of these new tetraspanins coincides in nearly all cases with the concomitant acquisition of new introns.
Numerous data in the literature have already reported that some cytoskeleton constituents are expressed in epithelial cells with concomitant acquisition of new morphological and migratory phenotypes, a phenomenon called epithelial-mesenchymal transition.
Our phylogenomic approach also allows the estimation of the time at which the introns of the 33 human tetraspanin paralogs appeared, which in many cases coincides with the concomitant acquisition of new introns.
Then, except for local structural rearrangements due to specific residues, the three PsTRXs show a concomitant acquisition of compactness, burial of hydrophobic residues, and acquisition of secondary and tertiary structures, with the presence of a molten-globule-like species at low pH.
Overall, these results suggest concomitant acquisition of proliferation and stemness potential by bone-isolated CSCs-like.
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The reorganization of the blastoderm into an epithelialized epiblast and hypoblast raised the possibility that epiblast formation may be concomitant with acquisition of cell fate.
The re-expression of IMP3 in KRASV12-transformed cells as well as in cells harboring an activating K-ras mutation indicates that IMP3 induction may be concomitant with acquisition of K-ras mutations.
Similarly, it has been shown that porcine neonatal spermatogonial stem cells (SSCs) express low levels of Oct3/4, c-Myc, and Sox2 and these levels and those of Nanog and Klf4 increased during culture concomitant with the acquisition of pluripotency [57].
In EMT, fully differentiated mesothelial cells undergo transition to a mesenchymal phenotype, a spindle-shaped morphology, concomitant with the acquisition of a mesenchymal marker, α-SMA.
These results indicate that the behaviour of cells changes concomitant with their acquisition of regional identity, resulting in the establishment of discrete morphogenetic domains within the neural plate.
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