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The functions and regulatory mechanisms of NDRG1 gene have not been conclusively evaluated in human bladder carcinoma cells.
However, the overall impact of generic substitution (GS) on global clinical and economic outcomes has not been conclusively evaluated.
53 The effectiveness of bariatric-metabolic surgery in diabetic patients with BMI less than 35 kg/m has not yet been conclusively evaluated.
Because BAPTA/AM increased basal COX-2 mRNA and PLC inhibitor U73122, known to be unstable under prolonged cell culture conditions [24], failed to decrease 20 4 LPC-induced COX-2 mRNA, the impact of intracellular Ca2+ on 20 4 LPC-mediated upregulation of COX-2 mRNA could not be conclusively evaluated.
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Numerous exploratory safety and efficacy end points were assessed and, as such, had no prespecified primary end point, and the study was not powered to conclusively evaluate its objectives.
Cell culture models of physiologically relevant Notch-ligand interactions have been reported [55], [57]; however, in vivo models will be required to conclusively evaluate the therapeutic potential of Notch1 antibodies.
The slight reduction in reaching performance in 6-OHDA+N rats as compared with vehicle was not significant but the sample size was too small to conclusively evaluate the effect (p = 0.315).
Further, due to the distributions of the network values for average and maximum shortest paths (measured with Dijkstra's algorithm [79]) between the top 10 genes we were unable to conclusively evaluate these parameters (95% of average shortest path values were 3 and almost 75% of maximum shortest path values were infinite).
Most policies are in early stages, making it impossible to conclusively evaluate their strength.
Thus, evidence from routine care is needed to conclusively evaluate the add-on effect of psychotherapy.
First, this intervention study will conclusively evaluate whether vitamin D therapy lowers the circulating human RAS.
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