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Over the years, HFOV has shown promise in animal models, but no conclusive benefits in humans have yet been reported.
No conclusive benefits have been reported in AD [ 244] whereas, in ATH, some benefits have been reported, notably in the ASTEROID trial of rosuvastatin [ 245, 246], although other trials failed to give unequivocal results [ 247].
However, this systematic review still did not reveal conclusive benefits for acupuncture, with the quality of evidence judged as very low by GRADE evaluation, due to the limitations of the included trials stated above.
57 58 A meta-analysis on the use of Chlorhexidine gluconate (CHG), however, yielded no conclusive benefits of CHG bathing on sepsis prevention (pooled relative risk: 0.65, 95% CI 0.40 to 1.05).
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However, no conclusive benefit was demonstrated among patients with HIV-associated TB meningitis in the same study, which was conducted in the pre-ART era [ 18].
Considering the conclusive benefit of laparoscopic surgery in postoperative recovery, expansion of laparoscopic surgery is inevitable as long as the clinical evidence is clarified.
Although MARS and Prometheus have shown biochemical improvements in AoCLF and ALF, additional studies are required to show conclusive benefit in short- and long-term survival.
However, whilst the popularity of this strategy has increased - including anecdotally in burns - the randomised controlled trials to prove conclusive benefit do not exist in the burns literature.
Despite the absence of data yet showing conclusive benefit of OC screening, most participants believed that a high uptake of it would reduce mortality and that screen-detected cancers would have an improved prognosis.
In addition, although not conclusive, the benefits associated with ALA seem to stem mainly from EPA and DHA, and as major consequence of ALA deficiency it appears that EPA and DHA are not adequately produced [ 31, 32].
The literature on weight management programmes consists primarily of uncontrolled interventions, whose data seems promising and shorter term controlled trials but not conclusive of benefit.
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CEO of Professional Science Editing for Scientists @ prosciediting.com