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In 2010 the British Medical Journal published a meta-analysis where they pulled together the results of thousands of patients in many glucosamine trials, and the authors were unable to show any conclusive benefit from taking glucosamine – but they did go on to say that patients taking it often are convinced of its benefit, and as it wasn't doing them any HARM, they could continue to do so.
However, no conclusive benefit was demonstrated among patients with HIV-associated TB meningitis in the same study, which was conducted in the pre-ART era [ 18].
Considering the conclusive benefit of laparoscopic surgery in postoperative recovery, expansion of laparoscopic surgery is inevitable as long as the clinical evidence is clarified.
Although MARS and Prometheus have shown biochemical improvements in AoCLF and ALF, additional studies are required to show conclusive benefit in short- and long-term survival.
However, whilst the popularity of this strategy has increased - including anecdotally in burns - the randomised controlled trials to prove conclusive benefit do not exist in the burns literature.
Despite the absence of data yet showing conclusive benefit of OC screening, most participants believed that a high uptake of it would reduce mortality and that screen-detected cancers would have an improved prognosis.
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Many of the schemes have yet to go live and it is too soon for any to claim conclusive benefits for children.
Over the years, HFOV has shown promise in animal models, but no conclusive benefits in humans have yet been reported.
No conclusive benefits have been reported in AD [ 244] whereas, in ATH, some benefits have been reported, notably in the ASTEROID trial of rosuvastatin [ 245, 246], although other trials failed to give unequivocal results [ 247].
However, this systematic review still did not reveal conclusive benefits for acupuncture, with the quality of evidence judged as very low by GRADE evaluation, due to the limitations of the included trials stated above.
57 58 A meta-analysis on the use of Chlorhexidine gluconate (CHG), however, yielded no conclusive benefits of CHG bathing on sepsis prevention (pooled relative risk: 0.65, 95% CI 0.40 to 1.05).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com