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We therefore think that these between group differences do not invalidate our conclusions of non-inferiority with regard to the clinical outcome and much lower TNF inhibitor use.
This assumption was further validated by the recent update of the TARGIT-A results, where the conclusions of non-inferiority remain unchanged for patients treated at the time of initial resection [ 10].
156 157 158 Since fewer participants are receiving the full intervention as intended, non-adherence can reduce the contrast between study groups leading to decreased study power and increased costs associated with recruiting larger sample sizes for evaluating superiority, or leading to potentially inappropriate conclusions of non-inferiority or equivalence.
Moreover, because of the little size of our seria, caution in the conclusion of non significant results of multivariate analysis is required.
Consequently, ρ O cannot be 1 since this makes other sensing probabilities zero, which contradicts the previous conclusion of non-zero sensing probability.
Usually, whenever Test 1 reaches the conclusion of non-statistically significant difference in percentages, this simply means that the current evidence is not strong enough to persuade the researcher that the two examined populations differ.
The continuous treatment arm had a higher than expected failure rate than used in the original statistical design which could impact on the overall conclusion of non-inferiority.
There are two caveats to the conclusion of non-specificity.
Therefore, the data support the conclusion of non-inferior efficacy.
Sensitivity analysis confirmed that the conclusion of non-inferiority implied by this confidence interval was robust to a wide range of plausible reasons for missing outcome data.
Furthermore, robenacoxib had numerical superiority to meloxicam for the primary end point (relative efficacy 1.029), which supports the conclusion of non-inferior efficacy.
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