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The conclusions formulated were not tested for other pathologies.
Since our focus was on the process of developing, implementing and evaluating care pathways, the conclusions formulated are likely applicable to other pathologies.
Direct comparison of the results presented herein with the conclusions formulated subsequent to analyses using conventional "top gene list" approaches [ 19, 20] defines the added value of this systems biology based methodology as follows.
Therefore, our conclusions formulated above are robust with respect to the choice of the normalization method, and, in more general terms, they should be valid for different estimates of the actual Bcd variance.
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For each type three questions have to be answered and a conclusion formulated of either 'low risk of bias', 'unclear/unknown risk of bias' or 'high risk of bias'.
In particular, this means that the Bcd data rescaled according to the alternative algorithm support the conclusion formulated above about different dynamical mechanisms of canalization for Bcd profiles of different amplitude.
Thus, the conclusion, formulated based on S100A2 and S100A6 methylation/expression in fibroblasts and keratinocytes, that gene-specific rather than long-range effects on chromatin structure is decisive in the regulation of S100 gene expression (Elder and Zhao 2002) seems to apply to the S100 gene cluster in other tissues as well.
In conclusion, formulating swine diets based on digestible AA rather than on total AA can reduce N excretion.
Overall conclusions are formulated in the conclusions section.
The conclusions as formulated by the authors are shown in Table 5, with formulations indicating no effects or inconclusive ones are shown in italics and formulations indicating firm conclusions are shown in bold typeface.
Numerical applications are presented and pertinent conclusions are formulated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com