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In agreement with this conclusion, a study of DAF-16 localisation reported no effect of the age-1(hx546) mutation under normal culture conditions [ 4]. age-1(hx546) is a reduction-of-function mutant rather than a null mutation and its molecular nature is unknown [ 15, 16].
In support of this conclusion, a study in India on normal-weight offspring with type 2 diabetes mellitus that were matched with controls of comparable age showed that the former had lower plasma HDL-C concentrations and higher values of plasma insulin [ 47].
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