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If neither criteria was met, the study would proceed to the second stage, recruiting an additional 20 patients (total n=53), concluding efficacy only if ⩾6 pCRs were observed.
Similar(59)
Thus, the more skeptical one is based on the prior information, the harder it is to conclude efficacy using the same pivotal trial data.
This limits the risk of wrongly concluding therapy efficacy, thereby meeting the methodological standards of a Phase II randomized study.
Both primary end points should be statistically significant to conclude early efficacy or futility as opposed to the final efficacy analysis where success was achieved if one of the primary end points was significant.
Based upon the various assays used to measure cellular uptake of liposomes, we conclude the efficacy of cytoplasmic delivery by AVE-liposomes to cells in culture.
If X t ≤ r t, futility is concluded; otherwise efficacy is concluded by rejecting H0.
12 This review concluded that efficacy of acetazolamide was lower with slow mode of ascent.
Based on these evidences, it was concluded that efficacy of HDF is largely restricted by inter-compartmental resistance [ 15].
The probability to conclude for efficacy at the end of stage 1 is α2 = 3.7 %, whereas p = 35.0%%.
We conclude that efficacy of effect is not overtly dependent on the number of manipulated neurons but rather on their specific connectivity and/or function.
Based on the differences seen when the blocker concentration increases, we conclude that efficacy level obtained with flow cytometry was higher than that of the microplate reader method.
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