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We conclude that targeting of the anticancer agent, doxorubicin, using HPMA copolymer conjugates bearing multivalent galactoside residues can improve their cytotoxicity.
In summary, we conclude that targeting the MEK pathway with immunotherapy combinations in TNBC has synergistic effects, particularly as a significant proportion of human TNBCs are MEK activated and MEK activation is associated with poorer clinical outcomes15.
"Although it is likely, we cannot yet conclude that targeting miR-10b will reverse metastasis," says the paper's lead author, Whitehead cancer researcher Li Ma.
Based on our own experience working with a model of metastatic rhabdomyosarcoma as well as the work of others, in this review we conclude that targeting a single receptor ligand pro-metastatic axis will not effectively prevent metastasis and that we should seek other more effective therapeutic options.
The report's authors conclude that "targeting the country's more dangerous roads and taken to any meaningful scale, a Complete Streets approach over time has the potential to avert hundreds of millions or billions of dollars in personal costs".
Thus, we conclude that targeting of an actin-binding activity to microtubules potentially capable of recruiting small filaments or oligomers is not sufficient to drive actin assembly in this assay.
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Hence, we conclude that targeted drug delivery by RMS-P3/RR to furin increases the treatment efficacy for RMS tumors.
We concluded that targeting Lck to a RE-like compartment is a conserved activity of lentiviral Nef proteins.
Over the last few years, hundreds of publications have reported achievements and promises of SRM in translational and clinical research, which concluded that targeting MS techniques are compatible with the rigorous requirements for clinical studies such as biomarker validation.
Based on those results, we concluded that targeting sequences (hooks) with a combined length of up to 130 bp cloned into the ADH1 promoter region would allow selection for insertion events during TAR cloning.
On the basis of a recent publication by de Bono et al. (2011) that administration of the inhibitor of androgen synthesis abiraterone in combination with prednisone in patients pretreated with docetaxel prolonged survival to 450 vs 332 days, it could be concluded that targeting the androgen signaling pathway in docetaxel-resistant prostate cancer in vivo is nevertheless a worthy therapeutic goal.
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