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Considering the target activity one can generally conclude that "target is target" regardless of whether the respective organism is a human or a pest.
However, and despite the large effect sizes observed, it is premature to conclude that target site variants play the pre-eminent role in permethrin resistance.
Because we found the same mechanism of resistance in multiple strains representing several field populations, we conclude that target site alteration is the most likely means that field populations evolve resistance to Cry2 proteins in Helicoverpa spp. Our work also confirms the presence in the insect midgut of specific binding sites for this class of proteins.
We conclude that target individuals express learned olfactory behaviour regardless of whether a surrounding group of larvae expresses that same or a different type of learned behaviour.
However, based on comparably enhanced posterior negativity for stress mismatch in the present unimodal study and the former cross-modal study, we conclude that target modality does not alter the polarity of the posterior negativity related to stress priming.
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We conclude that targets are prioritized over obstacles in movement control.
"Although it is likely, we cannot yet conclude that targeting miR-10b will reverse metastasis," says the paper's lead author, Whitehead cancer researcher Li Ma.
We conclude that targeting of the anticancer agent, doxorubicin, using HPMA copolymer conjugates bearing multivalent galactoside residues can improve their cytotoxicity.
Based on our own experience working with a model of metastatic rhabdomyosarcoma as well as the work of others, in this review we conclude that targeting a single receptor ligand pro-metastatic axis will not effectively prevent metastasis and that we should seek other more effective therapeutic options.
The report's authors conclude that "targeting the country's more dangerous roads and taken to any meaningful scale, a Complete Streets approach over time has the potential to avert hundreds of millions or billions of dollars in personal costs".
Hence, we conclude that targeted drug delivery by RMS-P3/RR to furin increases the treatment efficacy for RMS tumors.
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