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In spite of the obvious evolutionary relationship between the members of the chitinase/CLP groups across species, caution must be observed when trying to conclude functional relationships.
To conclude, functional TAA-specific CD8+ T cells distribute both to the skin and peripheral blood of patients after TriMixDC-MEL therapy.
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We conclude that functional protein pathway activation mapping revealed specific deranged signalling networks in BCP-ALL that could be potentially modulated to produce a better clinical outcome for patients resistant to standard-of-care therapies.
Therefore, further experimental analysis would be desirable to conclude the functional involvement of the motifs into transcriptional activity.
We conclude that functional assimilation, high gene turnover and selection might represent key features of HGT events in nematodes.
From these results, we conclude that functional actin polymerization is required for fast and regular engulfment in phagocytosis.
We conclude that functional Id2 expression is not required for Wnt1 to induce mammary hyperplasia and mammary tumors.
We conclude that functional mir-71 is required for animals to survive late into normal adulthood, and that mir-71 acts in a pro-longevity manner.
Furthermore, the authors conclude that functional resting-state connectivity within the DMN is involved in PD-associated saccadic hypometria, in particular in the vertical direction.
We conclude that functional SIRT6 protein is required for efficient stabilization of DNA-PKcs at chromatin in response to DNA damage.
Previous studies in haematopoietic cells have failed to conclude the functional consequences of the Q576R substitution on downstream signal transduction (19 22).
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