Although this set of experiments indicated a marked preference of Bcr/Abl for Erk2 activation and a correlation with IM resistance, they did not allow us to conclude a direct cause-effect mechanism yet.
However, Peak and Mott (2011) concluded that a direct effect of temperature on gs is relatively small when the VPDL is kept constant.
However, our results do not permit us to conclude that it was a direct effect of liraglutide on circulating ZAG, an indirect effect of the decrease in insulin levels, or improved insulin sensitivity.
Since these analyses were performed after controlling for local pollinator abundance and diversity (see Methods), we can conclude that network architecture itself had a direct effect on population performance independently on any pollinator-mediated effect.
They concluded that current evidence does not support a direct effect of rs1800795 polymorphism on the risk of sepsis and more investigations would be needed to evaluate the effect of this polymorphism on sepsis mortality.
After excluding changes in blood flow, the authors of the latter study concluded that '… another mechanism, such as a direct effect of sympathetic transmitters on inflammatory cells, may mediate the putative effects of the SNS on DTH responses.' Another clinically well recognized phenomenon after stroke is immunosuppression.
In general, however, we conclude that the rs16969968 variant does not exert a direct effect on the outcomes that is large enough to be detectable in our sample, owing to the lack of an association in never smokers.
Regueira and colleagues [27] found that in an endotoxemic pig model, administration of NE was associated with an improvement of hepatic mitochondrial respiration and concluded that this effect was probably mediated by a direct effect of NE on liver cells.
The authors concluded that the most likely mechanism of oxaliplatin neurotoxicity is a direct effect on voltage-gated Na+ channels rather than an effect on K+ channels or nerve terminal Ca2+ regulation.
We conclude that reduced replication fork progression rates and increased replication fork stalling are caused by a direct effect of JQ1 on replication, rather than perturbation of the S phase itself, or by an indirect effect of c-Myc depletion.
