I think that is one of the reasons that there is so much interest in making more concerted effort on understanding the real underlying mechanisms of the disease.
There has been a concerted focus on understanding the patho-physiological and molecular basis of complicated malaria in children, much less is known about it in adults.
Although multiple myeloma (MM) remains an incurable disease, there has been a concerted effort toward understanding its molecular pathogenesis, which has paved the way for the development of highly effective, novel therapeutic agents such as the immunomodulatory agents thalidomide and lenalidomide, and the proteasome inhibitor bortezomib.
To ascertain the mechanism by which helenalin induces Atg12 and LC3-B expression, we concerted our efforts in understanding the role of the transcription factor NF-κB p65 in helenalin induced autophagy.
In our collaboration on diabetes, for example, data generated by experimental colleagues contribute to modeling and building a concerted mathematical effort at understanding the disease.
Understanding the concerted function of these paths may be useful when designing therapeutic strategies aimed at removing cholesterol from the foam cells which occupy atherosclerotic lesions.
The PBP-catalyzed transpeptidation reaction is the target of β-lactam antibiotics, but their vast employment worldwide has prompted the appearance of highly resistant strains, thus requiring concerted efforts towards an understanding of the transpeptidation reaction with the goal of developing better antibacterials.
ESPCC remains a rare diagnosis, and concerted efforts into better understanding the biological mechanisms that underpin its pathogenesis and relationship to SCLC pathobiology is urgently warranted in order to improve clinical outcomes.
Further research in this area will shed more light on understanding the principles of concerted evolution at various levels.
In the past decade, concerted efforts have been directed to understanding the genomics, evolution and biological characterisation of these sister clades [ 1- 4].
