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We now propose a concerted model for IpaJ function that highlights its potential for programmable demyristoylation in vivo.
These unexpected observations and the concerted model developed provide an alternative mechanism of action for reversal agents that sensitize multidrug-resistant cancer cells to anti-cancer drugs.
The relatively low value of the nucleotide variability in the spacer regions of the three sequences treated here (Table 1) leads us to accept that their evolution has been according to the concerted model.
We propose a way of computing apparent Adair-Klotz constants from microscopic association constants and allosteric parameters of a generalised concerted model with two different states (R and T), with an arbitrary number of non-equivalent ligand binding sites.
In the H. didactylus case, although the concerted model is acting at locus level, at genome level, the presence of two types and the between-species clustering of the multigene family indicate a birth-and-death evolution model.
The results were consistent with a two-state concerted model in which P-glycoprotein exists in two conformational states, P(A) and P(B), where 2-chlorpromazine is transported by the conformer, P(A), and vinblastine by the conformer, P B).
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Here we analyzed the relative influence of the mosaic and concerted models of brain structure evolution in the Tanganyikan cichlids, a highly variable clade of ray-finned fishes and the epitome of adaptive radiation [ 18].
These are the Birth and Death model and the concerted evolution model [ 66, 67].
Under this model, contrarily to the concerted evolution model, new functional genes often evolve through regulatory or functional differentiation.
Traditionally it has been established that the 5S rDNA gene family is a paradigm for the concerted evolution model; however, although this is the most common model observed for this gene, in more and more studies that are published, it is concluded that the 5S rDNA gene family can follow a different evolution model.
A dispersed gene arrangement facilitates a birth-and-death evolution model [ 37]; therefore a clustered arrangement could be propitious for a concerted evolution model.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com