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Can events of concerted change be detected statistically in sequence data, and do they improve the characterization of evolution and the inference of evolutionary histories?
Linguists have long recognized concerted change that affects copies of the same sound (or phoneme) appearing in different words as a central feature of linguistic evolution [ 6].
Similarly, in another example, GNAS is differentially expressed in all nine cases, with a subset of cases showing concerted copy number change while the remaining cases reveal concerted change in DNA methylation.
We might expect concerted change to be a feature of evolving cultural systems where artifacts and institutions are hierarchically organized from a discrete set of repeatedly used building blocks (e.g., motifs, keystone technologies).
Next, we further refine this subset of genes from step 2 by selecting those having concerted change in all dimensions in the same sample which we term as MCD.
We hypothesize that regulatory mechanisms under water deficit induce a concerted change in metabolism that allows the cell to cope with the new condition and that leads to more dependent metabolic profiles.
Similar(35)
Coupling free energy in the absence and presence of changes elsewhere in the molecule is discussed in terms of specific folding models, including stepwise folding and concerted changes.
A new conductance analysis method applied to intracellular recordings in the somatosensory cortex of anesthetized rats revealed mirror changes of excitation and inhibition during the up- and down-states of slow waves, but concerted changes in conductance variances.
In one of the simulations, structural relaxation after the removal of regulatory ions led to concerted changes in the tilt of the pore helices, resulting in iris-like dilation and spontaneous hydration of the hydrophobic neck.
Put together, these data suggest that concerted changes in the conformation of specific residues facilitate the stabilization of nucleotide complexes thereby enabling the steps involved in the ping-pong reaction mechanism without large changes to the overall structure of this enzyme.
ErbB kinase-conserved residues in JM-kinase linker and β2-β3 loop also undergo concerted changes in the inactive dimer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com