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This protein binds mono- and di-methylated H4K20 and contains three MBT domains which act in concert to interact with methylated H4K20 (isolated MBT domains do not bind peptides, unlike bromodomains).
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Indeed, TET has recently been found to interact in concert with an array of epigenetic regulators, including transcription factors, histone modifying enzymes, chromatin-remodeling complexes, and miRNAs, suggesting a central regulatory role over the epigenome [ 54].
These regulatory factors are thought to interact in concert with a highly conserved and prototypic set of core promoter recognition proteins and co-activators that form the PIC at gene promoters.
MBD proteins are known to interact with methylated DNA in concert with HDACs to repress transcriptional activity via heterochromatin formation.
CHIP has been shown to interact with tau, appears to work in concert with both Hsp70 and Hsp90 in degrading toxic tau species (Saidi et al. 2015).
To perform this kind of action, different sensory modalities are used in concert to perceive and interact with multimodally specified objects and events [1] [5].
Also, HDAC1 has been shown to interact directly with the KDM5B protein [ 41], raising the possibility that both proteins may act in concert to modulate the early response to radiation.
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