Metastasis to the central nervous system (CNS) is a difficult concern to be resolved in many types of cancer as a result of inadequate penetration of antitumor agents, difficult accessibility, and neurological symptoms leading to a decreased performance status, and lung cancer is the leading cancer to metastasize to the brain.
Thus, we have a tendency to focus only upon the sensible, viewing it as a self-contained arena within which all questions of moral concern are to be resolved.
In the aftermath of the disorders of Stephen's reign in England there were many legal cases concerning land to be resolved: many religious houses had lost land during the conflict, while in other cases owners and heirs had been dispossessed of their property by local barons, which in some cases had since been sold or given to new owners.
Both governments tried to keep their disagreements out of public view, and after a meeting on Saturday night between General Dunford and Mr. Karzai, the president's office issued a statement saying that the transfer would now take place in the coming week, "allowing time for some of the remaining technical details concerning the handover to be resolved".
Therefore, there are significant safety challenges associated with the use of CSC-specific CART cells that are a concern and need to be resolved.
But CSF's capacity to support the wider use of ChildInfo is a concern, which has to be resolved for the future; and contractual arrangements also need revision.
Ethical concerns are never problems to be resolved once and for all; they make us uncomfortable and sometimes, when the sting of conscience is too strong, prevent us from sleeping.
In fact, whole human genome sequencing adds to the complexity of the genetic information that will be accessible, and raises great social concerns that still need to be resolved, such as possible forms of discrimination.
The significance of the EHEC outbreak analyzed here lies primarily in the fact that it raised epidemiological questions and public health infrastructure concerns that have yet to be resolved, and required the development of new resources for detecting and responding to newly emerging epidemics (2).
This is an issue concerning MAMR that needs to be resolved.
