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Concerns on potential risks to human health and the environment posed by use of engineered nanomaterials (ENMs) in food applications must, however, be adequately evaluated at the developmental stage to ensure consumer's acceptance.
While this single activity may lead to suboptimal radiation doses in neuroendocrine tumors (NET) with advanced or bulky disease, dose escalation has been withheld due to concerns on potential tumor somatostatin receptor saturation with reduced efficacy of the added activity.
Although especially the younger population exhibits a higher awareness on environmental issues, these movements seem to be mainly motivated by concerns on potential negative effects on the local communities (for example, direct pollution).
In general, the exploited tight gas reservoirs in Germany are located in greater depth (often > 3.500 m) than some of the shale gas and CBM reservoirs currently considered for exploration, which vary in depth but are located partly in depth of 1.000 m or less [2, 4 6], raising additional concerns on potential impacts on near-surface groundwater resources.
The use of inducible knockout mice can resolve this type of concerns on potential ectopic expression of transgene since the phenotypes can be directly compared in two groups of the same strain of inducible knockout mice with one group treated with dox and another group without dox treatment.
Our finding that Ukrain represents a mixture of Chelidonium majus L. alkaloids instead of the "Ukrain-molecule" further challenges clinical use of Ukrain and in addition rises concerns on potential adverse side effects of the drug preparation on liver tissue as observed for Chelidonium majus L. extracts [ 61, 62].
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While the contributions from these accomplishments also created an enhancement in the local economies and technological advancements, these activities also have raised significant concern on potential surface and groundwater contamination and air pollution issues and more recently induced seismicity for geohazard risk.
Recent concern on potential health hazard of different rubber chemicals has thrown the subject quite open to the scientists.
For curcumin itself, the prediction shows concern on potential HERG K+ channel blockage, and more seriously a very poor cell permeability index for both Caco-2 and MDCK tests.
The ethics committees limited the experimental conditions to 10% body weight or less, on concerns of potential injury to subjects with heavier loads.
This phenomenon combined with an increase in human mobility is raising major concerns on the potential diffusion in non-tropical countries of vector-borne diseases caused by arboviruses such as Zika, Dengue, West Nile and Chikungunya1,2.
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