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Routine use of ketorolac after cardiac surgery is limited by concerns of bleeding complications.
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These concerns include fear of bleeding complications (particularly with warfarin) and other side effects of medication (e.g., the risk for HIT conferred by heparins).
To optimise the validity of our findings, we were careful to control for the rhAPC treated group with a group of patients who were equally eligible for rhAPC treatment but who were not treated due to clinician concern of bleeding risks.
Physicians often avoid anticoagulation in elderly patients due to fear of bleeding, fall risk, non-adherence and monitoring concerns.
Data concerning presence/abundance of bleeding and mucus do not correlate with tissue viability (Rte), but interestingly there is a trend positive correlation between mucus and Rte (r = +0.078), indicating that presence of mucus (i.e. probably resulting from a less "aggressive" bowel cleaning) could somehow serve to preserve tissue viability (Table 2 and Figure 2).
Results of other studies concerning the risk of bleeding in patients taking LDA and undergoing endoscopic resection have varied.
In other situations, the patients declined biopsy out of concern for bleeding or infection.
However, concerns of increased risk of bleeding and other complications associated with early revascularization in patients aged ≥75 years persist.
Patients may choose anticoagulation over serial imaging however, to avoid the inconvenience of another scan if concerns about the risk of bleeding are insignificant.
Although heparin bridging has been reported to be effective in preventing thrombosis, several reports have raised concerns about increased risk of bleeding.
This is almost certainly the result of bleeding concerns should patients later be referred for coronary artery bypass graft (CABG) surgery.
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