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Trial discontinuation, non-publication, and non-contactable investigators represent a potential waste of research resources, leading to hidden trial data and ethical concerns for study participants.
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Additional concerns for studies with PE related to possible contradictory signals between different α1-AR subtypes and even whether there may be interaction with β-ARs.
Meta-analysis should incorporate the concern for study quality and differences in study design seen in classic review articles with the concern for rigor, objectivity, and quantitative precision characteristic of meta-analysis.
This non-specific association of proteins to highly active coding regions raises a potential concern for studies of transcriptional elongation.
Additionally, our results confirm previous findings of temporal changes in museum collections, and this will be of particular concern for studies testing intraspecific hypotheses relating temporal patterns to adaptation of eggshell colour.
These processes were a concern for studies using biochemical assays, and protocols were developed to minimize their occurrence.
This systematic error is concerning for studies using bioelectrical impedance to evaluate absolute fat mass and fat-free mass.
For the first time a SGOMSEC workshop also formally considered the issue of ethics in relation to methodology, an issue of particular concern for studies of susceptibility.
This may be a particular concern for studies of gene expression in the brain, for which we have no data at this time.
Reverse causality, however, is a concern for studies that measure PFAS levels in children already diagnosed with ADHD at time of blood draw.
Although a lack of blinding would not be a significant concern for studies using automated devices, many studies in the review used manual BP measurement, which is known to be subject to terminal digit preference, and so observer bias may have been an issue for some of these studies where blinding was not present.
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