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This agreed with previous work concerning small sample properties of the GEE model [ 20].
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The second limit concerns the small sample size of the study and the potential sample selection bias of the screening phase conducted by the consulting clinicians without performing a systematic between-center inter-rater reliability.
This is likely due to methodological constraints and concerns about small sample sizes.
A related concern includes small sample sizes of some of the datasets used to evaluate the method.
Kendall et al argue that the time consuming nature of data generation and concerns about small sample size should not deter researchers from using multiperspective qualitative interviews.
Owing to the concern of small sample size (n=4), respondents who smoked Forsyth, which is a private brand label, were also excluded from the analysis.
Finally, BMI and physical activity variables are correlated, potentially raising the concern of small sample sizes in specific groups crossed by BMI and MMW.
Another weakness of the study concerns relatively small sample size, which limited the possibility to include more potentially important modifiers of both GPx1 activity and TBARS levels, such as for example ER status.
In response to the reviewers' concern regarding small sample size, we would like to point out that while each panel in the figures may show data points for 4 to 6 mice in each group, the data are representative of at least 2 or 3 independent experiments.
Secondly, and more importantly, there are stability and power concerns that pertain in small sample settings [ 17].
A low reliability can be considered a limitation, but is mostly a concern in small samples where the risk of type 2 errors is inflated.
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