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During follow-up time, all patients were instructed to inform the study team concerning significant changes in their disease status.
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According to the recent literature concerning AMD, significant changes in the complement system have been observed, mainly in activation of several complement components [ 19].
As far as the histamine‐elicited transients was concerned, no significant changes were observed in the τon, peak [Ca2+]n, τoff, or AUC between the three cell types (Figs. 2C F).
Concerning p53, no significant changes in the total amount could be observed after rapamycin or H2O2 stimulation, but, in the presence of high levels of RAC3, p53 is predominantly localized at cytoplasm, as confirmed by western blot.
The concern about significant changes in the business environment (such as customer demands and transportation costs) has spurred an interest in designing scalable and robust supply chains.
Some research in the UK on public opinion suggests that landscape aesthetics of crops were of less concern than significant changes from the wider infrastructure of bioenergy plants including heavier traffic; people also wanted to know how the local community would benefit [10].
Concerning TSI scores, no significant changes were observed after 1 year.
No significant changes concerning the Raynaud syndrome were observed, although an angiologic examination was not performed as follow-up procedure.
"Over the past eight weeks, we have met with our trades union colleagues on over 40 occasions, listening to their concerns and making significant changes as a result.
Both collective and individual forms of involvement were of interest, as well as the impact of factors, such as organisational change and service reorganisation, topical concerns considering the significant changes in the structure of the NHS implemented by the UK coalition government since 2010.
Concerning the hematological data, no significant changes were encountered for all the parameters, except a reduction of PCT for the groups under ω-3 treatment (Table 2).
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