Therefore, PACAP-38 is likely to be an important factor in migraine pathophysiology; however, there is less evidence concerning its function in other primary headache disorders such as CH.
Therefore much remains to be understood concerning its function.
Although much is known about the anti-apoptotic ability of Bcl-2, little information is available concerning its function in other cellular processes, such as cell differentiation.
Lago, R., Gomez, R., Lago, F., Gomez-Reino, J. & Gualillo, O. Leptin beyond body weight regulation — current concepts concerning its role in immune function and inflammation.
We showed that the truncation of the disordered termini altered the folding state of the middle segment and has functional consequences concerning its physiological function.
The sequence needs to be connected to data that allows the useful interpretation of the results concerning its biological function, and it needs to be linked with primary databases like GenBank or PubMed.
Although many cells and tissues, such as blood lymphocytes, muscle, heart, kidney, digestive tract and skin, express PrPc [5] [9], most of the studies concerning its physiological function have been performed on nerve cells.
In the proteins that are specific for the Methanococcales (see Additional file 3(a)), one large gene cluster (MMP0233 MMP0240) is found, but no information is available concerning its possible function.
However, huge efforts are still needed to address its specific role in cell transformation, mostly concerning its apparently contradictory functions as a proapoptotic or prosurvival mechanism.
Although Xist is conserved in humans [ 1], very little is known concerning its regulation and function in this species.
We present data concerning its characteristics and putative function(s) and raise the question concerning the importance of this CRISPR array and other CRISPR systems in general.
