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The TEF approach is a special case of the RPF method, and uses "extensive mechanistic information that shows all toxic effects of concern share a common mode of action" to determine relative potencies (U.S. EPA 2000).
Anyway these results should be interpreted with caution, considering the small sample size and the fact that ED pathology and weight concern share issues such as fat anxiety, dieting, eating restraint or food and weight perception.
According to the U.S. EPA, "the RPF method uses empirically derived scaling factors that are based on toxicity studies of the effect and exposure conditions of interest in the assessment," whereas the TEF is based on "extensive mechanistic information that shows all the toxic effects of concern share a common mode of action" (U.S. EPA 2000).
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