When developing appropriate models to study tumor progression and metastasis it is essential to balance concerns of tissue fidelity and physiological relevance with the experimental accessibility of the system.
Use, interpretation, and significance of these parameters concerning assessment of tissue oxygenation are discussed elsewhere.
Finally, it should be kept in mind that our study and those quoted above concern different types of tissue.
Given the mechanism of action of rFVIIa, there was concern that activation of tissue factor at sites such as atheromatous plaques in patients with ischemic heart disease might precipitate clinically relevant coagulation and thrombosis.
Although it has been shown to have superior results, high-dose radiation therapy is not a current practice largely because of concerns of normal tissue toxicity.
Initially, strategies focused on the design of a support structure to perform a similar neuronal function as the gold standard of treatment, a nerve autograft, thereby eradicating the need of obtaining a donor nerve via lengthy or multiple surgical procedures as well as eliminating the concerns of donor tissue availability, resulting morbidities, and additional injuries and scarring [ 2, 13– 13].
ECHO findings should be appropriately interpreted in the clinical context and integrated with available data from other monitoring tools (systemic arterial mean pressure, central venous pressure and saturation, arterial blood lactates, urine output), especially with the ones concerning the adequacy of tissue perfusion, on which echocardiography is blind.
Analysis of specific tissue structures may be of particular interest concerning a possibility of tissue affinity for individual light chains.
Information is given concerning the preparation of tissue slices and the advantages of this procedure over corresponding in vivo techniques.
She attended a post-doc fellowship in Leuven, Belgium and leads research projects concerning the field of tissue bioengineering.
