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Arguments can be made that either of the search techniques provided a more representative sample of RCT manuscripts from the field of brain injury, but which search technique is superior – if either can be said to be so – is not a concern of the current study.
One potential concern of the current study is that we only tested limited variants in the functional region of CYP2E1 gene and left a relatively large region of introns unexplored, which is also not available in a chip-based genotyping assay.
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However, with very few records missing this potential source of bias should be of minor concern in the current study sample.
Financial difficulties were frequently listed as problems of most concern in the current study, followed by working conditions.
Some comments are necessary concerning the limitations of the current study.
Measurement error of dietary exposure was a major concern in the current study, as it is in all large cohort studies of diet and chronic disease.
It is of concern that in the current study, managers were least likely to have an education status of certificate/diploma level and above and none of them reported having had previous training in either the health or mental health fields.
The last argument concerns the very core of the current study.
Comment: My second comment is concerned with the implication of the current study in relation to Dyson's study [ 32, 49].
Limitations of the current study concern the representativeness of our sample from this hard-to-reach population and from the general population of pregnant women.
One important caveat of the current study concerns the extent of TH-Cre actinithein threehree VTA subpopulations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com