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A primary concern of association studies is the possibility that population sub-structure causes spurious associations [31], [32], [39], [40], a problem that could be particularly acute in a study such as ours, where diverse breeds may experience systematic differences in disease exposure.
However, a common concern of association studies is the high proportion of false positive or false negative tests of association of trait phenotype with causal genetic polymorphisms as well as the limited statistical power in detecting genuine associations [ 23, 24].
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One of the main concerns of association mapping is the spurious marker trait associations due to population structure (Krill et al. 2010).
In our three cases we decided to decrease the tacrolimus dose and cease mycophenolate mofetil, given our experience with reducing tacrolimus in BK viraemia and concerns of association of mycophenolate mofetil with PML.
"After the Stephen Lawrence inquiry there was a lot of activity within the Met and major inroads were made, but in recent years race has been put on the back burner and that has been a concern of the association," Powell said.
There was concern of its association with skin irritation and an initial flare, both troublesome adverse effects (AEs).
The primary reason parents sought care for their children was the severity of the illness and concern of its association with a medically serious state of dehydration.
It depends on federal and state laws and their enforcement to ensure respect for that right, along with other basic human rights in the work place (i.e. concerning freedom of association, forced labor, child labor and discrimination) as well as other decent and safe conditions of work.
By contrast, it said, professional education is usually not the primary concern of trade associations.
Concerning temporality of associations, a large cohort study using follow-up data over 12 years of adolescent and adult Canadians recently found childhood adversity and depression to be significant predictors of adult migraine.
Concerning the lack of association between DIV and "persistence" whilst it was associated with DV and IV, we acknowledge that it is a counter-intuitive finding.
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