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This concern is a significant practical one, given the operational purpose of IGRF models.
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Of further concern was a significant increase in cancers other than CRC, largely attributable to an elevated risk of prostate cancer (Cole et al, 2007).
Cardiovascular safety concerns are a significant cause of attrition in the development of new drugs (Lasser et al., 2002).
Yet, pedestrians are a vulnerable group of people and safety concerns are a significant barrier in one's decision to walk.
Thus, environmental justice concerns are a significant gap in our current knowledge base of how to adapt to and prepare for climate impacts.
Skin cancer is a significant health concern in minority populations.
Of significant sociological concern is a lack of jobs and housing.
Security concerns Lack of security is a significant concern for both Afghan citizens and humanitarian workers.
They also comment that caretakers' level of education and knowledge concerning the care of children is a significant factor.
For a group that has rarely seemed concerned with accessibility, "Merriweather" is a significant step toward a more polished sound and a wider audience.
"[Ice] is a significant concern on the national scale, and a significant concern on the territory scale," said Giles.
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