In this study only 5% of trials in which patient reported outcomes were ranked as irrelevant reported such outcomes, therefore dismissing any concerns for substantial misuse.
Streptococcus pneumoniae, a normal commensal of the upper respiratory tract, is a major public health concern, responsible for substantial global morbidity and mortality due to pneumonia, meningitis and sepsis.
Matthew Whittaker, senior economist at the Resolution Foundation and the author of the report, On Borrowed Time?, said: "Debt levels are a major concern for a substantial number of families struggling under a burden of repayments, even as things stand.
Deflationism about truth replaces a concern for a substantial theory of truth with a concern about which sentences, or utterances, are deemed to be truth-apt.
Nevertheless, production diseases such as mastitis still are of major concern and account for substantial economic losses for dairy farmers [ 2- 4].
The tendency of powder mixtures to demix due to segregation is a substantial technical concern for manufacturing of pharmaceutical solid dosage forms.
During the conference, President Rouhani addressed Iran's controversial and a decades-long nuclear program which has been a substantial concern for the International Atomic Energy Agency IAEAA), the international community, the United States, and its allies.
"It was just a matter of time". How the public will react to the disruption brought about by slower growth is a substantial concern for the Chinese government, analysts said.
"Duke's recent environmental problems suggest serious lapses in oversight as well as failures in risk management by the board of directors and are a substantial concern for investors," said Bill Dempsey, senior vice president of the Nathan Cummings Foundation, a social justice agency based in New York.
