A particular concern for interactions with picomolar affinities is that at high on-rate constants, diffusional transport to the surface becomes limiting, whereas for low offrate constants, the baseline stability of the instrument limits accurate measurement of slow dissociation kinetics.
53 The fact that it is excreted unchanged through the kidney raises concern for possible interaction with other renally excreted drugs like metformin.
From the information-processing point of view, division of labor means factoring the total system of decisions that need to be made into relatively independent subsystems, each one of which can be designed with only minimal concern for its interactions with the others.
ART was changed to lamivudine, tenofovir and raltegravir out of concern for drug interactions between voriconazole and efavirenz.
There was no concern for a possible interaction between hormonal therapy and BPs in HR negative patients.
Two patient groups were concerned about the impact of gout on their other health conditions, including hypertension, conflicting messages from doctors and their concern for drug-drug interactions.
Showing concern for how your interactions with others makes them feel shows that you are observant and caring.
With an increasing number of technologies supporting transactions over distance and replacing traditional forms of interaction, designing for trust in mediated interactions has become a key concern for researchers in human computer interaction (HCI).
These are obviously a systems focus, but also concern for context, acknowledgement of interactions and complexity, a holistic approach, recognition of emergence and embedding of the professional effort involved within organization system.
The real challenge concerns the need for interactions between all databases, all journals, and all research data, and will involve the commitment of entire communities.
