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In addition to the conceptual proof of potential applications of nanostructured PLLA matrices for controlled drug delivery, the strategy employed herein offers a new way to construct bioactive scaffolds, such as antibacterial or anti-inflammatory scaffolds, which may find broad applications for tissue regeneration and stem cells-based biotherapy.
This conceptual proof of oxidative stress as a major disease-driving factor in X-AMN warrants translation into clinical trials for X-AMN, and invites assessment of antioxidant strategies in axonopathies in which oxidative damage might be a contributing factor.
Furthermore, we present compelling evidences that the chosen antioxidant combination halted clinical progression and reversed axonal damage in the mouse model, thus providing the formal conceptual proof for oxidative injury or at least an antioxidant-sensitive process as a main etiopathogenic factor in this disease.
Further, we recently reported that a combination of antioxidants halts clinical progression and reverses axonal damage in the X-linked adrenoleukodystrophy mouse model, thereby providing formal conceptual proof that oxidative injury is a major aetiopathogenic factor in this disease (Singh and Pujol, 2010; Lopez-Erauskin et al., 2011; Galea et al., 2012).
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To further validate the conceptual designs, proof of concept prototypes have been constructed.
We review the available data from animal and human studies that provide the conceptual basis, proof-of-concept and illustrations of success of such combination strategies in experimental and clinical paradigms in other conditions.
One of the key design challenges when creating an environment that directs motions for a sophisticated conceptual area like geometric proof is determining which actions to direct to best facilitate students' reasoning.
It is an enticing piece, possessing, like much of Heatherwick's work, both the wit of an epigram and the conceptual elegance of a mathematical proof.
In this work, proof of a conceptual and innovative design of an endoscopic piezoelectric tactile sensor is presented.
Immersions are nonetheless a useful conceptual stepping stone for constructing proofs about embeddings, since all embeddings are necessarily immersions.
In such situations the major conceptual recasting will also produce new proofs but the explanatoriness of the new proofs is derivative on the conceptual recasting.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com