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The broad acknowledgment of these conceptual differences for T-cell vaccine led to a dedicated regulatory guidance for therapeutic cancer vaccines, and the acknowledgment to perform concomitant studies of the magnitude, phenotype and function of vaccine-induced immune responses to better understand the anticipated mode of action and to guide the development of new vaccines [ 1– 3].
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Authors' response: According to our experience the conceptual difference of CpG islands and spanion clusters is a major issue for the potential readers.
Also conceptual differences can be observed as, for example, we are left with two routes for both the conversion of citrate to isocitrate.
For this strategy, we introduce the term "node-to-element integration" for its conceptual differences to node-to-segment approaches.
This difference can be explained by the conceptual differences captured by these tools, for the HFSSM has a narrower definition of food hardship than the other two instruments.
There are, however, conceptual differences in the probability estimation approaches for those SVM machine-learning approaches which have generally been proven to provide consistent estimates (for a discussion, see Malley et al. 2011).
A possible explanation for this finding relates to conceptual differences.
Our detailed comparison of five metabolic networks and the identification of the conceptual differences between the databases provide a stepping stone for their integration.
The methodological and conceptual differences between r8s, BEAST, and some other methods available today for molecular dating have been reviewed by several authors [ 12, 14, 22- 24].
Understanding the conceptual differences between mixed and marginal beta regression models is important for their proper use in the analysis of longitudinal HRQL data.
To enable integration of the networks, next to a need for standardizing the metabolite names and identifiers, the conceptual differences between the databases should be resolved.
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