As a proof of concept, we designed and synthesized the conjugate prodrug of hydrophilic gemcitabine by its covalent coupling to hydrophobic chlorambucil via a hydrolyzable ester linkage.
For proof of concept, we designed a series of peptides based on the high aggregation prone C-terminus of Aβ42, which is associated with Alzheimer's disease.
As proof of concept, we designed and synthesized probes for caspase-3 activity (Z-DEVD-SiR600) and leucine aminopeptidase activity (Leu-SiR600).
Based on this concept, we designed a muscle-synergy-based EDTE as a framework for EMG refinement, which regulates the abovementioned uncertainty of individual EMGs in consideration of unmeasured muscles.
As proof of concept, we designed and synthesized a xanthene-based photosensitizer, TGI-βGal, whose oxidative stress induction ability is switched on following hydrolysis reaction with β-galactosidase, a widely used gene marker.
As a proof of concept, we designed the current study to explore whether individuals without EEG training can detect ongoing seizures by simply listening to one channel of sonified EEG instead of viewing 20+ channels of EEG.
In order to exploit this concept, we designed an auxiliary classifier that classifies the source user type of a tweet into two categories - organizations and individuals.
In line with this concept, we designed an intraoperative fluid management protocol where minimal fluid maintenance with a crystalloid solution (fluid restriction) was combined with the administration of fluid boluses in case of severe and documented hypovolemia.
To adhere to that concept, we designed a transcriptional termination ('Stop') element entailing two loxP sites (34 bp) flanking a herpes simplex virus thymidin kinase polyadenylation site (70 bp) and a polyadenylation terminator (154 bp).
The course concept we designed can be implemented in groups with a maximum of 20 students.
