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The concept, put forward by Wakefield and colleagues [ 54], is that since excessive TGFβ action is mostly localized within the tumor, TGFβ inhibition could be therapeutically advantageous.
The PAINS concept put forward by Baell et al. is a milestone event for medicinal chemistry and drug discovery, just as the first detection of frequent hitters by McGovern et al. has been more than a decade ago.
Another new and fertile concept put forward by Jacques Monod dealt with the lactose permease, a membrane-associated protein, believed to allow bacterial cells to pump β-galactosides from the medium (Rickenberg et al 1956).
This molecular similarity between normal and malignant stem cells re-enforces the concept put forward by the cancer stem cell model, according to which stem cells and early progenitor cells are more susceptible to transformation than their differentiated counterparts [ 3].
Only one is listed in the table Expression of pathogen effectors in plants is a perfect example of the "extended phenotype", a concept put forward by Richard Dawkins [ 36] in his classic book "Extended phenotype: The long reach of genes".
In line with the pathophysiological concept put forward by Joan Braganza, oxidative stress caused by ROS is known to be proinflammatory and favors acute and chronic pancreatitis by direct damage of cells as well as by activation of inflammatory cells and pancreatic stellate cells [ 109].
The concepts put forward in this 1923 review are on target with exciting more-recently published data [ 90- 92].
It has made for what I'm told is a "rollercoaster" relationship between the project and the people of Hamburg, as up and down as the hall's roof, ever since 2003, when Herzog & de Meuron's concept was put forward by Alexander Gérard, a property developer who owned the warehouse.
The quasispecies concept was put forward by Manfred Eigen and Peter Schuster [ 21] within the framework of physical chemistry.
