In this chapter, we introduce and discus current concepts of tissue engineering with particular focus on future clinical application.
This foreshadows a novel concept of tissue repair relying on secretion of trophic factors and/or crosstalk with the microenvironment rather than MSC transdifferentation.
The concept of tissue engineering is based on that fact that by cultivating postnatal dental stem cells (DSCs) on a well-designed bioengineered three dimensional scaffold, it is possible to regenerate tooth organogenesis.
Withers et al. originally introduced the concept of tissue radiation tolerance based on functional subunits (FSUs), which can be either arranged in parallel or in series.
In addition, the legal concept of "Tissue Establishment" was introduced, which expands on the conventional concept of a tissue bank.
The concept of tissue and cell guidance is rapidly evolving as more information regarding the effect of the microenvironment on cellular function and tissue morphogenesis become available.
Lay one tissue on a flat surface.
We expect our results could provide knowledge on oxygen distribution in 3-dimensional spheroidal cell structures and critical design concept for tissue engineering applications.
It is important to note that enhancer and silencer are relative concepts here, which describe the relative function on exon inclusion in one tissue comparing to another tissue.
This is an important concept because arterial PO2 has a profound and incompletely understood effect on tissue PO2.
