This is followed by experimental investigations in which design concepts are established.
Two simple concepts are established in the literature that systematically link the individual (eco toxicity of the components of a mixture to its total toxicity, termed Concentration Addition (CA, also known as Dose Addition) and Independent Action (IA, also termed Response Addition), see review by Kortenkamp and colleagues[6].
Before a final scheme of concepts was established, the concepts grouped under a certain ICF domain were sent back to the local investigators for evaluation and feedback.
Thirty detailed concepts corresponding to the previous described concepts were established, each being evaluated for validity across countries and disease conditions.
Once the major concepts were established, we completed detailed coding to identify sub-themes, connections between codes, and inclusion and exclusion criteria (Appendix 2).
The main modification is that different levels of the concepts are established: oral status or impairments, intermediate impacts (pain, discomfort, functional limitation or dissatisfaction with appearance), and ultimate impacts which cover the concepts of disability and handicap.
A list of detailed concepts was established from patients' own words, from which a test questionnaire was developed and validated by the Advisory Committee (AC) consisting of three diabetes specialists/endocrinologists, one psychiatrist and two general practitioners.
As this journal undergoes an expansion in focus and nomenclature from cerebrospinal fluid (CSF) into all barriers of the central nervous system (CNS), this review traces the history of both the blood-CSF and blood-brain barriers from as early as it was possible to find references, to the time when modern concepts were established at the beginning of the 20th century.
