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Background: We performed a proof of concept trial to evaluate relative safety and efficacy of Rhodiola rosea (R. rosea) versus sertraline for mild to moderate major depressive disorder.
The potential efficacy of acoustic CR modulation was shown in a clinical proof of concept trial, where effects achieved in 12 weeks of treatment delivered 4-6 h/day persisted through a preplanned 4-week therapy pause and showed sustained long-term effects after 10 months of therapy, leading to 75% responders.
Of 34 pet dogs on the proof of concept trial, 23 had the cells transplanted into the injury site - the rest were injected with a neutral fluid.
Since PANTHERIS as proof of concept trial was not designed to demonstrate clinical superiority of preventive antibacterial treatment in a routine environment and ITT analysis revealed only a trend towards beneficial effects of preventive antiinfective treatment caution is needed.
PB participated in developing the study concept, trial conduction and coordinated the immuno monitoring.
KJ: Worked with AMcG on concept, trial design, outcome measures and literature reviews.
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